At MImAbs SAS, we’re addressing the challenges of generating antibodies against difficult targets such as GPCRs and tetraspanins. By combining mRNA immunization with the Bruker Beacon® single-cell screening platform, we’re dramatically accelerating antibody discovery.

We are thrilled to have presented this poster at SITC (Society for Immunotherapy of Cancer), showcasing how our cutting-edge methods are advancing therapeutic antibody development.

Key Innovations :

· mRNA Immunization: Overcoming traditional challenges like low immunogenicity and recombinant protein production issues.

· Single-Cell Screening: High-throughput screening and rapid antibody sequence recovery.

· Alloy Humanized Mice: Increased antibody diversity and significantly shorter development timelines compared to conventional approaches.

Highlights from our work :

· Enhanced diversity of paratopes detected with Alloy mice.

· 26 unique antibodies identified in a single campaign using mRNA and single-cell screening.

· Reduced development time compared to traditional hybridoma approaches.

Check out our poster below for more details :

lnkd.in/dseZsimp

#AntibodyDiscovery #Beacon #SingleBcell #Innovation #Biotechnology #mRNAImmunization #GPCRs #HumanizedMice #DrugDevelopment