The therapeutic benefit of pro- or anti-inflammatory mAbs is monitored using two main, non-exclusive mouse models of inflammation available at MImAbs:
LPS-induced inflammation model
DSS / TNBS models: MImAbs (to come)
Genetically modified model: CIPHE
Inflammation assays consists on inducing an inflammatory response in mice, treating the animals with the mAb of interest, and sampling blood to measure the levels of pro-inflammatory cytokines in the bloodstream by flow cytometry.