Mouse Models for Inflammation

Mouse Models for Inflammation

The therapeutic benefit of pro- or anti-inflammatory mAbs is monitored using two main, non-exclusive mouse models of inflammation available at MI-mAbs:

  • LPS-induced inflammation model

  • Colitis model:

    • DSS / TNBS models: MImAbs (to come)

    • Genetically modified model: CIPHE

Inflammation assays consists on inducing an inflammatory response in mice, treating the animals with the mAb of interest, and sampling blood to measure the levels of pro-inflammatory cytokines in the bloodstream by flow cytometry.